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Because the route of administration affects how B12 reaches the body, one product cannot automatically be substituted for another

This assumption was based on limited early human data and laboratory observations

The pH of a product can affect the effectiveness of other ingredients

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It does not mean that the product is automatically cheap, ineffective or inferior

In a treatment-naive cohort studied in metabolic cages, administration of acyl-GIP at the onset of the dark phase decreased food intake and RER (Extended Data Fig